Dementia with Lewy Bodies (DLB) - Symptoms, Causes and Treatments

Dementia with Lewy Bodies (DLB) - Symptoms, Causes and Treatments

“Lewy Body dementias” is a term referring to two closely related disorders: dementia with Lewy bodies (DLB) and Parkinson disease-dementia (PDD).  

DLB is typically managed by neurologists specializing in memory because initial symptoms are cognitive and behavioral, whereas PDD is typically managed by movement disorder experts, since initial symptoms mainly affect motor function.  

Symptoms of DLB may include

  • Fluctuations in attention and alertness that can vary dramatically even within the same day.
  • Visual hallucinations, delusions, mood swings and/or agitation.
  • Spontaneous movement that looks similar to Parkinson's disease.
  • REM sleep behavior disorder (physically acting out dreams with movements and vocalizations).

While the exact cause of DLB is not known, it is characterized by the accumulation of abnormal protein deposits in the brain (Lewy bodies), composed of “alpha-synuclein”.

Treatment approaches

  • Cholinesterase inhibitors, which often provide more noticeable up-front improvement for DLB patients than for Alzheimer's patients.
  • Medications like carbidopa/levodopa for movement symptoms when they significantly affect mobility or daily tasks.
  • Non-pharmacological approaches can help with behavioral symptoms like mood swings.


Learn more about the other memory disorders we treat at Neura Health.

Neura Health’s memory specialists are ready to help you or a loved one living with DLB, and offer video appointments within just one week, on average. These short wait times mean more opportunities for early intervention.  Book a video visit today!

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David Weidman, MD, FAAN
Dr. David Weidman is a board-certified neurologist and advisor at Neura Health, with specialized training in dementia disorders.
About the Author
Dr. Weidman is an adult neurologist, fellowship-trained neurophysiologist, clinical research trialist, memory disorders specialist from Banner Alzheimer Institute-Phoenix (BAI-P), and a Clinical Associate Professor of Neurology at Arizona University College of Medicine-Phoenix. He has served as the site-Principal Investigator at BAI-Phoenix within Arizona’s Alzheimer’s Disease Research Center. He has relatively broad clinical and clinical research trialist skills, with expertise in diagnosing and staging mild cognitive impairment, Alzheimer disease (AD), and related neurodegenerative disorders. Understanding whether and which interventional trials are appropriate for volunteers and patients--based on their clinical presentation, the nature of their cognitive symptoms and functional status, and comorbidities--has been another area of expertise he has developed.

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